Recent Advances in Proteinuric Kidney Disease/Nephrotic Syndrome: Lessons from Knockout/Transgenic Mouse Models

Proteinuria is known to be associated with all-cause and cardiovascular mortality, nephrotic syndrome defined by the level of proteinuria hypoalbuminemia. With advances in medicine, new causative genes for genetic kidney diseases are being discovered increasingly frequently. We reviewed articles on proteinuria/nephrotic syndrome, focal segmental glomerulosclerosis, membranous nephropathy, diabetic disease/nephropathy, hypertension/nephrosclerosis, Alport rare diseases, which have been studied mouse models. Significant progress has made understanding genetics pathophysiology thanks science, but research this area ongoing. In future, analyses patients proteinuric disease/nephrotic may ultimately lead personalized treatment options.